The bidirectional relationship between metabolism and cell cycle Biology Diagrams Uncovering cell cycle-associated metabolic processes is therefore of interest to find new avenues toward controlling cell proliferation. A number of observations suggest that some aspects of cellular metabolism are indeed coordinated with cell cycle progression.
The relationship between metabolism and cell cycle progression is complex and bidirectional. Cells must rewire metabolism to meet changing biosynthetic demands across cell cycle phases. In turn, metabolism can influence cell cycle progression through direct regulation of cell cycle proteins, through nutrient-sensing signaling pathways, and
Mapping metabolic oscillations during cell cycle progression Biology Diagrams
In conclusion, while incompletely understood, cell cycle progression is tightly coupled to intracellular metabolism. Emerging evidence suggests that intracellular kinases such as AMPK and mTOR can sense energy intermediates such as AMP, ADP and amino acids and subsequently direct how biosynthetic intermediates are used and whether the cell
During cell-cycle progression, metabolism is regulated to sustain schematically protein synthesis in G1 phase, nucleotide synthesis in S phase, and lipid synthesis in G2 phase. In G1 phase, until the cell growth step in mid-to-late G1, several glycolytic enzymes are inhibited by cycD-CDK6 and APC Cdh1 complexes, the latter also reducing TCA
Metabolic control of the cell cycle Biology Diagrams
Regulation of cell proliferation by metabolism evolved in part to cope with nutritional deprivation, explaining why mechanisms arose to reduce cell growth and arrest cell cycle progression in conditions of starvation. 5 A key regulatory step early in the G 1 phase of the cell cycle is the growth factor-dependent restriction point, when cells
